Pharm MOD 1 Discussion Group 1 During clinical, you argon charge to care for a client receiving morphine IV for affirm of postoperative pain. The clinical instructor has assigned you to formulate the followers: A) What are the major differences between narcotising agonists, narcotising agonists-antagonists, and somniferous antagonists? Narcotic agonists are drugs that fight back with the opioid receptors throughout the body to piss analgesia, sedation, or euphoria. These drugs are highly habit-forming (p. 408). Narcotic agonists-antagonists react with some opioid receptor sites to stimulate performance and block opposite opioid receptor sites. These drugs are not as addictive as pure narcotic agonists (p. 414). Narcotic antagonists, which piddle to reverse the effectuate of narcotics, are used to treat narcotic overdose or to reverse unacceptable unbecoming effectuate (p. 417). B) Describe the cure actions, indications, contraindications, the mo st common adverse reactions, and most-valuable drug-drug interactions for a narcotic. The narcotic agonist act at ad hoc opioid receptor sites in the CNS to bring analgesia, sedation, and a consciousness of well-being. They also are used as antitussives and as adjuncts to world(a) anesthesia to produce rapid analgesia, sedation, and respiratory natural depression.
Indications for narcotic agonists include relief of exhausting acute or chronic pain, preoperative medication, analgesia during anesthesia, and specific somebody indications, depending on the receptor similarity (p. 409). Narcotic agonists are contraindicated in the follow ing conditions: presence of cognise anyerg! y to any narcotic agonist to avoid hypersensitivity reactions; looseness of the bowels caused by toxic poisons because depression of GI practise could campaign to increased absorption and perniciousness; and after biliary mathematical operation or surgical anastomoses because of the adverse effects associated with slowed GI activity due to narcotics. Oxycodone is classified as pregnancy category B, whereas all of the other...
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